10 ways to prevent communicable diseases
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Dont leave food out refrigerate promptly. Executive Editor,Harvard Women's Health Watch. Choose a healthy diet deliberately. This makes the person vulnerable to other infections and diseases. They live in grassy and brushy areas and are most prevalent during wet seasons. 3. *When helping a child, wash their hands first, and then your own. Beware of animals 8. Some helpful tips to prevent the spread of infectious diseases are-. Many other important conditions are also considered NCDs, including injuries and mental health disorders. Make sure your pet's vaccinations are up to date, too. Bureau of Communicable Disease Control and Prevention Missouri Department of Health and Senior Services PO Box 570 Jefferson City, Missouri 65102-0570 Telephone: 573-751-6113 Fax: 573-526-0235 Email: info@health.mo.gov. Needles should never be shared, should only be used once, and then thrown away properly. The Centers for Disease Control and Prevention (CDC) recommends washing your hands thoroughly and vigorously with soap and water for at least 20 secondsabout as long as it takes to sing "Happy Birthday" twicefollowed by hand drying with a clean towel or air drying. 2019;8(1):139. doi:10.1186/s13756-019-0595-2, Desai AN, Mehrotra P. Medical masks. The most important way to protect yourself from communicable diseases is to practice good hygiene. Stay clear of wild animals. Fungi are a type of organism that includes yeasts, molds, and mushrooms. Many viral illnesses can be prevented with vaccinations. This also includes food poisoning, which is caused by any one of more than 250 possible contaminants (including bacteria, viruses, parasite, toxins, and chemicals). Watch the area closely for a couple of weeks for signs of rash or swelling. Any serious cut or animal or human bite should be examined by a doctor. Suggest Corrections 1 Similar questions Q. Leapfrog hospital safety score, magnet designation, and healthcare-associated infections in United States hospitals. Keep your pets away from wild animals, too. Thorough hand-washing is particularly important before preparing a meal or eating, after using . Vaccination can also reduce the chances of contracting many diseases. Do not eat uncooked vegetables, including lettuce; do not eat fruit you haven't peeled yourself. Importance of maintaining a healthy lifestyle and controlling the disease. Jaan A,Rajnik M. TORCH complex. Do not consume dairy products (milk may not be pasteurized). Maintain proper hygiene and lifestyle practices to prevent infectious diseases, including washing your hands, avoiding touching your face, and keeping your immunizations up to date. Use animal-proof trash cans to avoid attracting wildlife, and teach small children that wild animals should never be approached or touched. Centers for Disease Control and Prevention. In addition, using separate cutting boardsone for raw meats and the other for producecan prevent cross-contamination. Don't use the same utensils or cutting boards with cooked meat that were used to prepare the raw meat without washing between uses. Ringworm is a common fungal infection of the skin. If no tissue is handy, cough or sneeze into your elbow rather than into your hands. Protecting Yourself from Communicable Disease Clean your hands! Wash your hands frequently when you are traveling to avoid transferring germs to your body via your hands. Maintain good personal hygiene 2. Many bacteria are harmless, and some help the body to function. Cardiovascular health: Insomnia linked to greater risk of heart attack. Use protective means such as masks and gloves to prevent contracting as well as spreading any infection. The World Health Organization's low-cost, AIDS: Communicable (YES) 14, Pink Eye: Communicable (YES) 10, physical inactivity, Target 5: Reduce tobacco use, and others.NCDs may be chronic or acute.Most are non-infectious, Other important ways to slow or stop disease transmission are by ensuring the food we eat and water we drink is safe . Four main types of pathogens cause infection: Viruses, bacteria, fungi, and protozoa. Keep the house ventilated 10. How to Reduce Your Risk of Infectious Diseases. The following can help prevent infections from bug bites: Controlling the population of mice or rats in and near your home can help you avoid pathogens spread by rodents and also help control the population of ticks that spread disease. Some common examples of non-infectious diseases include. The symptoms of HIV may develop gradually and in stages. Henning Bundgaard, Johan Skov Bundgaard, Daniel Emil Tadeusz Raaschou-Pedersen, et al. Both you and your partner should be tested for HIV and other sexually transmitted diseases. You can prevent infections by food-borne pathogens in your household by preparing and storing foods safely. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Why do we need to control and prevent non communicable diseases? Protect Yourself. Your immune system can fight off the virus as long as you are not immunocompromised and get enough rest and nutrients. Saliva and mucus spread this disease. The protozoa Plasmodium genus causes the tropical disease malaria. Boil all tap water before drinking or drink only bottled water; use bottled or boiled water to brush your teeth. Get vaccinated against seasonal and common communicable diseases such as the flu. 4 Regular physical activity is key to staying healthy by reducing the risk of chronic disease, including heart disease, diabetes, stroke, and some types of cancer. Some potential symptoms include: A person can catch influenza viruses in the same way they may catch rhinoviruses. 1100 San Leandro Blvd. Do not stir up dust in rodent-infested areas. It is projected that in near future, NCDs will account for nearly 70% of the mortality in developing world. Get moving. 27 Sources By Ingrid Koo, PhD Get your shots before you leave the United States. (2014). 2. Once a pathogen has entered a persons body, it often will begin replicating. Healthcare systems, government, and individuals should act responsibly to prevent the spread of communicable diseases. Some drugs, known as antiviral or antiretroviral drugs, can fight off certain viruses by taking away their ability to reproduce their DNA inside your cells. This allows you to build up your immunity and be more prepared to the native pathogens present at the areas where you are travelling to. The main risk factors of NCDs can be classified into the categories of self-management, genetic factors, environmental factors, factors of medical conditions, and socio-demographic factors. Noncommunicable, or chronic, diseases like heart disease and diabetes are having an increasing effect across the globe. If you suspect you have an infectious disease, consult your doctor immediately. Other medications can help prevent a person from contracting HIV. The first line of defense is to keep germs at bay by following good personal hygiene habits. 4. 3. Create a solution of 3 percent hydrogen peroxide to soak the toothbrush. Immunise against infectious diseases Wash and dry your hands regularly and well Stay at home if you are sick Cover coughs and sneezes Clean surfaces regularly Ventilate your home Prepare food safely Practise safe sex Immunise against infectious diseases Immunisation is a way of preventing infectious diseases. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight lossfrom exercises to build a stronger core to advice on treating cataracts. They treat bacterial infections, not viruses. Our hands can carry germs, so it is important to wash them often, even if they dont look dirty. Learn these healthy habits to protect yourself from disease and prevent germs and infectious diseases from spreading. Wash your hands every time after going to the bathroom, changing a diaper, sneezing or blowing your nose and when coming into contact with bodily fluids. Taking antibiotics when you dont need them (such as when you have a viral infection) increases bacterial resistance to antibiotics. Preventable communicable, or infectious, diseases like malaria and HIV/AIDS account for millions of deaths in the world each year, especially in low-income countries. These include receiving available vaccinations, practicing regular handwashing, and maintaining good hygiene at home. Learn more about the different types of pathogens here. There are steps a person can take to reduce their risk of contracting and transmitting disease-causing pathogens. Choose a healthy diet deliberately. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Healthy Resolutions For New Year. They typically spread through contaminated foods, such as uncooked meats and eggs, unwashed fruits and vegetables, and contaminated water sources. To help prevent these problems, drink fluoridated water, brush with fluoride toothpaste twice a day, and floss daily. Common viral, bacterial, fungal, and protozoa diseases include: Rhinoviruses are a group of viruses that are the most common cause of the common cold. Top 10 Non-Communicable Diseases. If water and soap is not available, use an alcohol-based hand sanitizer and rub it from your fingertips to your wrists in order to eliminate pathogens. Can poor sleep impact your weight loss goals? Centers for Disease Control and Prevention. Wash your hands with soap and water. HIV attacks the immune system of its host. Hand-to-face and hand-to-mouth transmission are among the most common ways that infectious diseases are spread. Vaccinescan prevent many infectious diseases. Staying healthy involves many different day-to-day habits. Do not pick at healing wounds or blemishes, or squeeze pimples. Check your neighborhood and pick up trash, discarded cans, bottles, and other containers that can contain enough water to allow mosquitoes to breed. Besides maintaining a proper hand hygiene, try to avoid touching your face, even with clean hands. MMWR. Hand washing with soap and water is the simplest and one of the most effective ways to prevent transmission of many communicable diseases (Figure 2.5). Don't pick your nose (or your mouth or eyes either). When outdoors, do not disturb rodent burrows or handle rodents. 2 2. You wash your hands frequently AND, you ask others to do the same, providing gentle reminders for them to do so when they may have forgotten. What Is the Incubation Period for the Flu This Year? AJN, Am J Nursing. Discuss your travel plans with your physician at least three months before you leave. Wash Your Hands. Get vaccinated 3. Thoroughly rub your hands using anti-bacterial soup. It is important to understand that antibiotics cannot cure or treat viral infections, such as the cold or flu. Always wash fruits and vegetables. Kraay ANM, Hayashi MAL, Hernandez-ceron N, et al. Always wash fruits and vegetables. The CDC's website also offers up-to-the-minute travel notices about outbreaks and other health concerns (both domestic and international), as well as advisories about outbreaks of food-borne infections. Someone close by can breathe in your air, or touch a surface contaminated with your germs, and become ill. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Germscan live on surfaces. Influenza viruses are infections that attack the respiratory system. A technician obtains a sample of blood by inserting a needle into a vein, usually in the arm. Prevention and control of infectious diseases. Xiong WM, Xu QP, Li X, Xiao RD, Cai L, He F. The association between human papillomavirus infection and lung cancer: a system review and meta-analysis. Preventing noncommunicable diseases Preventing noncommunicable diseases Reducing the major risk factors for noncommunicable diseases (NCDs) - tobacco use, physical inactivity, unhealthy diet and the harmful use of alcohol - is the focus of WHO's work to prevent deaths from NCDs. Non-communicable diseases, also known as chronic diseases or non-infectious diseases, are not caused by infectious agents but are instead the result of various non-infectious factors such as lifestyle choices, heredity, and environmental factors. The effects of private rooms on hospital-associated infections. More items. Antibiotics include a range of powerful drugs that kill bacteria or slow their growth. Plus, get a FREE copy of the Best Diets for Cognitive Fitness. Seal holes and cracks in your home to deter rodent access. Prevent infection before it begins and avoid spreading it to others with these easy measures. In addition to protecting your pet, this will also protect you and your family. 5 Work exercise into your daily . It is the most common carrier-spread disease in the United States. Vaccination does more or less the same thing, exposing the body to a weakened or killed form of the pathogen so that the same defensive cells are produced. In this case, several readers have written to tell us that this article was helpful to them, earning it our reader-approved status. Some communicable disease spread though the air. What is the difference between Salmonella and E.Coli? Wash hands, utensils, and surfaces often when preparing any food, especially raw meat. If you have to pet or hug people, wash your hands and pet or hug pet or hug the pet. Meningitis, inflammation of the protective membranes around the brain and spinal cord, causes nausea, vomiting, sensitivity to light, and confusion. The times when hands must be washed are indicated in Box . To reduce your risk of hospital-acquired infections: These preventive practices should extend to outpatient facilities as well, particularly if you may be immunosuppressed. By being smart about safe sex (using condoms), transfer of infectious bacteria or viruses from one person to another can be prevented. The best way to prevent infections is to block pathogens from entering the body. This can reduce your risk of infection and your risk of infecting others. Cough or sneeze into a tissue or your shirt sleeve-not into your hands. However, some can be serious and potentially life threatening. 7 7. Ketamine for treatment-resistant depression: When and where is it safe? Even now, although we know that microscopic living microbes cause disease, how they do so is not always obvious. Use topical antibiotic ointments for small wounds that are infected. Read about what are communicable diseases & how to prevent For more information, . MNT is the registered trade mark of Healthline Media. Viral infections: These are infections caused by viruses, such as the flu, HIV, and hepatitis. Some communicable diseases may be mild, and symptoms pass after a few days. Living in an affluent country like the United States, the threat we face from deadly viruses, bacteria, and parasites can seem remote, but these infectious microbes are ever present among us, according to Dr. Michael Klompas, writing in the Harvard Medical School Special Health ReportViruses and Disease. Dogs, cats, or any other type of warm-blooded animal can pick up rabies from wild animals and pass rabies along to people. Fungal infections: Protect your health. Check your pet before allowing it indoors. You will be subject to the destination website's privacy policy when you follow the link. Laboratory tests. Changes in color and texture and strange odors are signs that your food has spoiled. Learn, practice, and teach healthy habits. Prevention of NCDs is a growing issue: the burden of NCDs falls mainly on developing countries, where 82% of premature deaths from these diseases occur. Thank you, {{form.email}}, for signing up. Learn about resources for cleaning, respiratory and hand hygiene, and preventing the spread of infections in your early care and education program. Am I at Greater Risk of Coronavirus If I Have HIV? [2] Athletes foot is a common fungal infection that affects the skin on the feet. COVID-19 Guidance for Operating Early Care and Education/Childcare Programs. Clear brush and junk away from the foundation of your home. There are 10 references cited in this article, which can be found at the bottom of the page. Many wild animals, including raccoons, skunks, bats, foxes, and coyotes, can spread rabies to humans by biting. Some symptoms are a direct result of the pathogen damaging the bodys cells. By signing up you are agreeing to receive emails according to our privacy policy. Foodborne germs and illnesses. Some people will not experience any symptoms. Once inside, they use the cells machinery to make copies of themselves. How long do bacteria and viruses live outside the body? For oral sex, use a latex or polyurethane male condom or a female condom. Has two or more layers of washable, breathable fabric, Fits snugly against the sides of your face without gaps. 1. Most of these diseases can be passed from person to person so the words "contagious" or "infectious" are often used when talking about communicable diseases. In: StatPearls [Internet]. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. The immune system responds by producing antibodies capable of killing an active form of the virus in the future. Another way to prevent infection is to live a lifestyle that keeps you healthy: Eat a healthy diet, get routine exercise, and engage in stress reduction. Japanese encephalitis virus (JEV) 20 November 2022. Infect Drug Resist. Proton-pump inhibitors: Should I still be taking this medication? Safe antibiotic use is another strategy that helps prevent the spread of infectious diseases. doi:10.1097/PTS.0000000000000378, Rosenberg K, Todd B. Don't miss your FREE gift. Many communicable diseases cause mild symptoms that go away without treatment. Science and our food supply. Using hand sanitizers is also helpful. Bring a germ-filtering mask if you are in a semiprivate room or ward. However, many bacteria are developing a resistance to antibiotics, which poses a major health risk. Wash your hands well. [1] Face masks became a part of people's everyday lives with the onset of the COVID-19 pandemic. Get adequate sleep at night. Educational website from one of the world's leading hospitals Learn more about parasitic infections here. Signs of infection include redness, swelling, warmth and pain. X They can be transmitted via bodily fluids and food. Get tested for STDs before and after engaging in sexual activities with a new partner so that you are aware of your status. Centers for Disease Control and Prevention. Anju Goel, MD, MPH, is a board-certified physician who specializes in public health, communicable disease, diabetes, and health policy. Examples of diseases spread from faeces: Campylobacter infection Cryptosporidium infection Giardia infection hand, foot and mouth disease hepatitis A meningitis (viral) rotavirus infection Salmonella infection Research shows that infectious diseases can be caused by bacteria, viruses, or other organisms that enter the body through a wide range of methods. Treatment depends on, Airborne diseases transmit between people when droplets containing microorganisms remain suspended in the air, for example, after a person coughs. Hospital-acquired infections, known as nosocomial infections, are a significant cause of illness and death in the United States and around the world. Food can carry germs. Microbes thrive on virtually all food items, particularly foods left at room temperature. Reduce stress. And they may be transported into your home by your pets. Not only is it a social taboo, but it also leads to the spread of a number of infections. It has been declared a Communicable Disease Incident of National Significance. Not long ago, no one understood that infectious diseases were caused by tiny organisms that moved from person to person. Symptoms will vary depending on the disease. 1. You need a strong immune system to fight off infectious diseases. 2018;18(1):540. doi:10.1186/s12879-018-3425-x, Stephens B, Azimi P, Thoemmes M, Heidarinejad M, Allen J, Gilbert J.Microbial exchange via fomites and implications for human health. The faeces may be passed: directly from soiled hands to the mouth indirectly by way of objects, surfaces, food or water soiled with faeces. Good hygiene: the primary way to prevent infections The first line of defense is to keep germs at bay by following good personal hygiene habits. Salmonella can also spread through contact with live animals, including chickens, and through person-to-person contact. Communicable diseases are diseases that can pass from person to person. Wet your hands thoroughly. 10668 20. These objects are referred to as fomites, a term used to describe objects or materials that can carry infection, such as clothes, utensils, or furniture. 1. Cookies used to make website functionality more relevant to you. Non-communicable diseases (NCDs) are of increasing concern for society and national governments, as well as globally due to their high mortality rate. Some cancers are related to viral infections, including sexually transmitted ones like human papillomavirus (HPV). Vaccines are a highly effective method for preventing specific viral infections. Apply more and repeat. Children should receive the recommended childhood vaccinations. That's not an option for most people, so the next best choice is to follow these safer sex guidelines: If you do have sex with a new partner, make sure the partner is tested, and take the following precautions: Both mosquitos and ticks are carriers of viruses and bacteria. Although there is no cure for HIV, medications can help to keep the virus under control or make it undetectable. Traveler's health: food and water safety. Fortunately, you can help reduce the spread of infection in your facility by following these steps, reports the World Health Organization (WHO). Don't share dishes, glasses, or eating utensils. (2021). Avoid Sharing Personal Items Toothbrushes, towels, razors, tissues can all be sources of communicable diseases. Make sure you and your family are up-to-date on your vaccinations. Be careful when traveling to exotic countries Bibliographic references Help your students stay healthy with this unit on communicable and non-communicable illnesses and diseases. Palliative care frightens some people: Heres how it helps, Parents don't always realize that their teen is suicidal. The Best Diets for Cognitive Fitness, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. If your rodent problem is severe or persistent, consult a pest control expert. Learn how to put on and remove a face mask. They exist in almost every environment on earth, including inside the human body. While many pathogens have a low risk of transmission via fomites, there are some that are potentially spread this way. Antimicrob Resist Infect Control. Get the latest in health news delivered to your inbox! 2012 Aug 10;61(31):586-9. Thanks.". Viral gastroenteritis. Kwok YLA, Gralton J, McLaws M-L. Face touching: a frequent habit that has implications for hand hygiene. Include your email address to get a message when this question is answered. Are hospital floors an underappreciated reservoir for transmission of health care-associated pathogens? Maintain proper hygiene and lifestyle practices to prevent infectious diseases, including washing your hands, avoiding touching your face, and keeping your immunizations up to date. Coughing and sneezing. You should always contact your doctor or other qualified healthcare professional before starting, changing, or stopping any kind of health treatment. A common hiding place is in wet leaves. wikiHow is where trusted research and expert knowledge come together. However, you should disinfect your bathroom and kitchen regularly. One of the most important healthy habits to prevent the spread of germs is to clean your hands. Smith DS. Solution Two ways to prevent communicable diseases are as follows: GENERAL WAYS: Regularly clean and disinfect the places or surfaces which are commonly used. There are millions of different fungi. When washing your hands, use soap and warm water to wet your hands up to your wrists and scrub the skin for at least 20 seconds or more. 2015;43(2):112-4. doi:10.1016/j.ajic.2014.10.015. The following is a list of the top ten ways you can reduce the risk of zoonotic diseases. What are the four ways of controlling communicable diseases? wikiHow marks an article as reader-approved once it receives enough positive feedback. Centers for Disease Control and Prevention. Another form of salmonella, Salmonella typhi, can also cause typhoid. Trustworthy Source These medications can help to kill bacteria or slow them down so the immune system can counteract them. Haque M, Sartelli M, Mckimm J, Abu bakar M. Health care-associated infections - an overview. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.cdc.gov/drugresistance/biggest-threats.html, https://www.cdc.gov/features/rhinoviruses/, https://www.niaid.nih.gov/diseases-conditions/coronaviruses, https://www.cdc.gov/flu/symptoms/symptoms.htm, https://www.cdc.gov/fungal/features/fungal-infections.html, https://www.who.int/news-room/fact-sheets/detail/malaria, https://www.aad.org/public/diseases/a-z/ringworm-overview, https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/symptoms-of-hiv, https://www.lung.org/lung-health-diseases/lung-disease-lookup/tuberculosis, https://www.hhs.gov/immunization/basics/types/index.html, https://www.hhs.gov/answers/public-health-and-safety/what-is-the-difference-between-salmonella-and-e-coli/index.html. Infections are caused by microscopic organisms known as pathogensbacteria, viruses, fungi, or parasitesthat enter the body, multiply, and interfere with normal functions. Thanks for visiting. It is also important to avoid picking your nose or biting your nails, especially if your hands are not washed. These conditions include cancers, cardiovascular disease, diabetes and chronic lung illnesses. 9. All information these cookies collect is aggregated and therefore anonymous. Stop any bad habits. Educate and mobilize communities to help prevent the spread of major . Lyme disease can spread to the joints, heart, and nervous system if a person does not treat it. U.S. Food and Drug Administration. If in a public place, use the paper towel to turn off the faucet. If a tick has attached itself to you or your pet, grasp it firmly with tweezers close to the tick's mouth and pull steadily. Pathogens such as viruses, bacteria, and fungi cause these diseases. Current outbreak list. The following measures can help you avoid getting sick from diseases transmitted by animals: By Beverly Merz 10 ways to prevent communicable diseases. 3. Some fungal infections may be treated with a topical ointment if the infected site is on your skin (such as foot fungus). 2019;119(11):53. doi:10.1097/01.NAJ.0000605376.45065.6b, Song X, Vossebein L, Zille A. Efficacy of disinfectant-impregnated wipes used for surface disinfection in hospitals: a review. Many NCDs can be prevented by reducing common risk factors such as tobacco use, harmful alcohol use, physical inactivity and eating unhealthy diets. Bring antiseptic wipes or handwash (or ask the hospital to provide them for you). We are monitoring the unfolding situation in Australia concerning the Japanese encephalitis virus (JEV). A person should only ever take antibiotics on a medical recommendation. Nontyphoidal Salmonella and Escherichia coli (E. coli) are two different types of bacteria that can infect the digestive system. Then, throw in the trash. Prepare your food responsibly by limiting cross contamination. How can we prevent communicable diseases Wikipedia? People sometimes refer to communicable diseases as "infectious" or "transmissible" diseases. This includes chemotherapy infusion centers (where you get treatment for cancer) and dialysis centers (treatment center for help removing waste products and fluids from your blood to aid your kidneys). 2023 by The President and Fellows of Harvard College, Do not sell my personal information | Privacy Policy. Preventing Non-Communicable Diseases (NCDs) NCDs are the 21st century's foremost threat to health, well-being and prosperity. High-income is the only category of income group in which there have been decreasing numbers of deaths from these two diseases. Make healthy food choices "For good health and disease prevention, avoid ultra-processed foods and eat homemade meals prepared with basic ingredients," says Dr. Todorov. When a person receives a vaccine, they are receiving a form of the virus. Some protozoa are parasitic, meaning they live on or inside another organism and use the organisms nutrients for their own survival. JAMA. Lather up with soap or cleanser, and rub it into the palms and backs of your hands and your wrists. Make sure that your pets vaccinations are up-to-date. 3 3. 2. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Many infectious microbes can live on surfaces anywhere from a few minutes to several months at a time, depending on the environment and pathogen (disease-producing microorganism). In addition to vaccines and safe food handling habits, you can reduce your risk of coming down with or spreading an infectious disease with a few everyday practices. avoiding touching wild animals. If you have a compromised immune system (have reduced ability to fight infections), you may need to go one step further by cooking meats until well done and peeling or scraping all vegetables and fruits. Defrost foods only in the refrigerator or in the microwave. Avoid getting any unnecessary shots, immunizations, or tattoos abroad. Avoid The Use Of Tobacco With this in place, your immune system may be better able to defend against some mild community-spread infections. When a virus enters your body, they hijack your bodys cells to multiply and spread to neighboring cells. Infections that can spread from animals to people, called zoonotic diseases, are more common than some may realize.

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10 ways to prevent communicable diseases