steve kirsch fluvoxaminecommon last names for slaves in the 1800s
See this Wall Street Journal op-ed. Online. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. So there were too few events in the placebo group and they werent recruiting fast enough. Now they turn to Rust. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. So far, doctors have failed to share his sense of urgency. In September, he resigned as CEO and gave up his board seat. This post was written to memorialize the corruption. Proven in clinical use all over the world. So much for evidence-based medicine. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. 1991-1992 to 7.1% in 2001-2002. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. But they dont want their names used. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . The incident, he added, was completely in keeping with his personality.. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. But the potential upsides. Most recent articles first. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. I wanted to get the article out before my flight left. Theres nothing there.). . Online Status. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. 1 hr ago. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. The web price charge of skirsch.io . People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). If you take fluvoxamine, please avoid caffeine while on the drug. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. I have all of these on hand and I load up on vitamin D3 every day. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. That receptor also helps regulate the body's . In some cases, youd want to taper down the dosage. Vitamin D, NAC, betadine, aspirin, and Nigella sativa are all super cheap, effective, and available without a prescription. I fully expected both organizations to do absolutely nothing. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. As noted before, the repository has a link to the 1 hour serotonin lecture. 36m "We found Fauci was the most highly compensated federal employee. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. The evidence is solid. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Steven Todd Kirsch is an American entrepreneur. So why would we wait when lives are being lost? My crime? I fully expected both organizations to do absolutely nothing. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. This looks ominous, but it harmless. Another CETF grant, though, yielded far more exciting results. Author Affiliations . A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. Still, in the moment, his question threw me, and I stuttered. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. Has it really been 25 years, a whole quarter of a century? The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. It is not unusual to be wary of developing science, or wrong to be skeptical of pharmaceutical companies. In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. One of the drugs, Fluvoxamine, showed a 30 . Steve Kirsch is baffled. Steve Kirsch. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. MD, MPH; Steven C. Marcus, PhD. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. No long haul symptoms if you start the drug ASAP after first symptoms. He retired at the largest pension in federal history. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. I have never heard of a case it didn't work. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. I bumped up the reward to $1M. Timing is everything with respect to outcomes. Some countries dont have fluvoxamine so this is the alternative. The effect size is huge if the drug is given early right after symptoms start. Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. So much for evidence-based medicine. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. 4000fluvoxamine750 Some are views most scientists think are wrong. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. Your best bet is to. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). . My website www.skirsch.io has tons of info on fluvoxamine with all the links. You can use fluoxetine as well (aka Prozac). The paramedics will think you are on drugs. No more. This drug can save your life but you have to ask for it! Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. If you start later, doctors use higher dosages and compliance becomes a bigger problem. The NIH wrote a bullshit rejection because the FDA told them not to approve it. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? Now weve lost the high ground, Morris told me. I have all of these on hand and I load up on vitamin D3 every day. There were no studies reported out so far where fluvoxamine made things worse or neutral. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. It is perhaps the greatest unnecessary loss of life in American history. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. I think we did rigorous reviews of proposals for research.. This is the gold standard of evidence based medicine. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. How covid-19 conspiracy videos keep getting millions of views. Once the Phase 2 result came out, it should have been embraced by doctors. Steve Kirsch is an inventor of the optimal mouse, a Silicon Valley millionaire, and an MIT alum (Class of '80). This give another 50% of benefit. Last Checked: 03/03/2023. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. That way you can start immediately. There are other non-prescription things you should always have on hand. including the very promising Fluvoxamine. (One of them, Eric Lenze, was in fact giving a presentation on fluvoxamine to the National Institutes of Health the next day.) Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? I will . . We could have saved a lot of lives. One is to reduce the threat of nuclear war. Steve Kirsch is a Silicon Valley philanthropist. I mean, he really, truly has a heart of gold, Char told me. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. That is when the phase 2 results were published. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. It is very important to educate doctors because most people rely on their doctors for advice. Those days are gone. Fluvoxamine was reportedly added to just 2 practice guidelines (. This is why Cliff doesnt talk to me. . We could have saved a lot of lives. . In short, a lot of mumbo jumbo. See my article on treatments. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. And FrameMaker is still a niche product. Physicians who use the drug for COVID now swear by it. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. But even she was drained by Kirschs constant attempts to override the data. Their willingness to lie did. NIH is still unsure whether fluvoxamine should be used to treat COVID. Fluoxetine is just as effective. The choice couldn't be more clear cut. This advice is now outdated. Zero. Dosage there is 30mg once a day. Government agencies are ignoring the science. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. My website. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. May 16, 2022. . It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. . Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. He has a BS/MS in Electrical Engineering and Computer Science from MIT. Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. Talking to Kirsch is an exhausting experience. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. 21. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. . All the medical journals refused to publish the meeting notes (rejected by 6 journals). Long haul. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. It doesnt get any better than this. Waiting months for the phase 3 trial to complete is nuts. In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. saying that the per-protocol analysis was arbitrary and other excuses. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. Thats what creates some of these heroes.. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. That way you can start immediately. Telling the truth, he tweeted. Hes very convincing. He started 7 high tech companies, two with billion dollar market caps. He has been a medical philanthropist for more than 20 years. Medium revoked my account for life. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Comparison with molnupiravir. See more below. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. (Siliciano did not respond to requests for comment for this article.). Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. Here is the latest version. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. No long haul symptoms if you start the drug ASAP after first symptoms. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). Once the Phase 2 result came out, it should have been embraced by doctors. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. This is what the Seftel trial at Golden Gate fields used. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. The study was also featured on 60 Minutes. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Compulsive hand washing? Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. He has made millions from these projects, even if they have not turned him into a household name. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Thats pretty typical, but your mileage may vary. I fixed the link to the fluvoxamine article. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. There are 4 outpatient studies that have been done (2 at WashU (see. It will be months before enrollments are complete. Ive used it personally at 50mg twice a day and experience no adverse events at all. A very short op-ed arguing for using fluvoxamine against COVID. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . Several other trials around the world are in the final stages, too. If you cant get a prescription for COVID, then perhaps you have OCD? and increased heart rate (which could be nerves about the dilated pupils). Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. Hes spending his own money to do what he thinks is right. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Added to FLCCC protocols and Fareed-Tyson protocol among others. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. It was tested in. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). The next major effect is that that fluvoxamine activates the sigma-1 receptor. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). The anecdotal data of 100% success rates is further icing on the cake. I learned this the hard way. All the medical journals refused to publish the meeting notes (rejected by 6 journals). Theyre finding alternative leaders to follow, Morris said. Im not going to make the same mistake again.. I think so. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. The NIH never did a risk benefit analysis of this drug. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. The data is there in plain sight for anyone to see today. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. Its the gold standard of medical evidence. It works best when it is given early, as soon as symptoms start. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. just like ivermectin). Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. I was just getting tired, he said, before asking to speak off the record. Why not fluvoxamine? We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. All have had a 100% success record in keeping their patients out of the hospital. I couldnt tell I was on the drug. I took it myself at that dosage and noticed zero side effects.